Actelion Pharmaceuticals Ltd (VTX:ATLN) Corporate news announcement processed and transmitted by Hugin AS. The issuer is solely responsible for the content of this announcement. ---------------------------------------------------------------------- --------------



Dear all,

Another year is rapidly coming to an end. 2008 was marked by turmoil in many aspects, but I will remember yet another year of close contact with you, pleasing both professionally and personally.

I hope that the holiday season ahead will give us the necessary peace of mind and soul to start anew in 2009. I very much look forward to another year of working with you. With so much clinical newsflow ahead, there will be plenty of opportunity for us to interact.

Thank you very much for your ongoing interest in Actelion and a festive season!

Please click on the link below to see the Season's Greetings from Actelion: http://www.actelion.com/xmas2008/xmas.html

Best regards

Roland Haefeli VP, Investor Relations and Public Affairs Member of the Actelion Executive Committee Actelion Pharmaceuticals Ltd / Gewerbestrasse 16 / CH-4123 Allschwil / Switzerland phone +41 61 565 64 58 / fax +41 61 565 65 07 / mobile +41 79 704 42 15 / from the US: +1 650 624 6936 / roland.haefeli@actelion.com / www.actelion.com Address for visitors: Hegenheimermattweg 91

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Actelion Pharmaceuticals Ltd Gewerbestrasse 16 Allschwil Switzerland

WKN: 936767; ISIN: CH0010532478; Index: SBIOM, SLIFE, SMCI, SMIEXP, SMIM, SPI, SPIEX; Listed: Main Market in SWX Swiss Exchange;



LINK: http://www.actelion.com/xmas2008/xmas.html

Actelion Pharmaceuticals Ltd

http://www.actelion.com

ISIN: CH0010532478

Stock Identifier: XSWX.ATLN

US: OTC:ALIOF

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